Kollia et al. (2003) demonstrated that iron import proteins might complement one another in acute myeloid leukemia cells. Yang et al. (2001) showed that in tumor tissue from 42 breast cancer patients, expression in both the transferrin receptor and ferritin H-chain was significantly correlated, and that the abundance of ferritin H- chain transcripts was directly related to the status of axillary lymph nodes, the presence of metastasis disease and the clinical stage. The gene discussed is TFRC; the disease is neoplasm.