Although some of the criteria used here to diagnose the LFL phenotype were not stringent (i.e. Eeles criteria used to classify LFL phenotype) and may have little sensitivity for identifying germline TP53 mutations in other countries, the unexpectedly high number of criteria-positive patients suggests that LFL may indeed be a common phenotype for hereditary breast cancer in and around Porto Alegre. The gene discussed is TP53; the disease is Hereditary breast cancer.