Woodward et al. (2005) reported three BRCA2 rearrangements in 25 families with at least one male breast cancer, but no BRCA2 rearrangements in 114 families without male breast cancer, and Tournier et al. (2004) described three BRCA2 rearrangements in 39 French families with at least one case of male cancer. These findings indicate that large genomic rearrangements in BRCA2 are more frequent in families with male breast cancer. Here, BRCA2 is linked to breast cancer.