GATA4 and Abnormal heart morphology: Mutations in the GATA4 gene have been found in patients with congenital heart defects (Garg et al., 2003; Okubo et al., 2004; Hirayama-Yamada et al., 2005; Sarkozy et al., 2005), but no mutations have been related to upper-limb malformations so far.