The association of schizophrenia and single-nucleotide polymorphisms (SNPs) of ERBB4 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 4), enconding one of the receptors for NRG1 has been shown, thus suggesting that NRG1-ERBB signaling is involved in the pathogenesis of schizophrenia (Benzel et al., 2007). The gene discussed is NRG1; the disease is schizophrenia.