In order to investigate the relationship between the ERBB3 gene and schizophrenia in the Chinese population, we carried out case-control and family-based studies of the ERBB3 rs2292238 polymorphism, using samples consisting of 470 cases matched by controls and 532 family trios (composed each one by normal parents and a single affected offspring), all of Han Chinese origin. This evidence concerns the gene ERBB3 and schizophrenia.