CTLA4 and autoimmune disease: Associations previously described between susceptibility to some autoimmune diseases and CT60 polymorphism have been interpreted considering the possible effect of this SNP in the alteration of the ratio of CTLA-4 splicing isoforms, and that elevated levels of sCTLA-4 have already been detected in certain autoimmune disorders (Ueda et al., 2003; Saverino et al., 2007; Kawasaki et al., 2008).