IGHE and asthma: A background history of recurrent and reversible symptoms of air passage obstruction, high serum IgE levels, positive test results to at least one of the recognised allergens inoculated in skin, and a family history of allergy were required for AA diagnosis, in accordance with current Global Initiative for Asthma (GINA) criteria (GINA Report, Global Strategy for Asthma Management and Prevention, 2009).