Adiponectin gene activity has an important influence on the susceptibility to insulin resistance, a core determinant of prevalent disorders such as type 2 diabetes mellitus (T2DM), metabolic syndrome and atherosclerosis (Hara et al., 2002; Menzaghi et al., 2002, 2007; Rothenbacher et al., 2005). The gene discussed is ADIPOQ; the disease is atherosclerosis.