TGFB1 and breast carcinoma: By anchoring HER2 to actin skeleton, TGF-β also induces clustering of HER2 and integrin α6, β1 and β4, which is mediated by focal adhesion kinase (FAK) and required for TGF-β-induced motility and oncogenic signaling of HER2 in breast cancer cells (Figure 1) [57].