These capillary augmented lesions in IPF patients are susceptible to acute lung injury, not only because these capillaries reduce the ability to antagonize HMGB1 but also because VEGF, which is elevated (augmented) in these lesions [15], loosens the tight junctions of endothelial cells so as to induce leakage [36, 37]. The gene discussed is HMGB1; the disease is idiopathic pulmonary fibrosis.