Thus, we analyzed the in vitro IL-1β, IL-23 and IL-6 secretion by MoDCs cells after stimulation with TLR ligands in 4 active CAPS patients (2 CINCA and 2 MWS) with NLPR3 mutation, 4 active SoJIA patients and 9 healthy controls. The gene discussed is IL1B; the disease is systemic-onset juvenile idiopathic arthritis.