In the present study, several evidences suggest the existence of a TH17 skewed phenotype in NLPR3-mutated CAPS patients: i) CAPS patients showed increased levels of serum IL-17, ii) stimulated PBMCs displayed higher frequency of IL-17 producing cells compared to healthy controls; iii) monocytes-derived dendritic cells from CAPS patients displayed increased production of IL-1β and IL-23. The gene discussed is IL17A; the disease is cryopyrin-associated periodic syndrome.