Furthermore, it has been suggested that this polymorphism was also associated with depression [18,32-35], we have reported previously that there was no significant association between depression and this SNP [19] and we argue that the previous reports of MTHFR C677T association with depression can be explained by the high prevalence of migraine in depressed subjects included in these studies. The gene discussed is MTHFR; the disease is depressive symptom measurement.