Mutations in several transcription factor genes notably paired box 6 (PAX6), forkhead box E3 (FOXE3), eyes absent homolog 1 (Drosophila; EYA1), and v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian; MAF), and paired-like homeodomain 3 (PITX3) have been implicated in both congenital cataract and anterior segment mesenchymal dysgenesis (ASMD) [5-10]. This evidence concerns the gene PAX6 and anterior segment dysgenesis.