M1 macrophages secrete IL-12 and NO, promote antitumor immunity and directly kill tumor cells, whereas alternatively activated M2 macrophages exhibit defective production of IL-12, high IL-10 secretion, produce arginase, suppress the antitumor response and promote angiogenesis and metastasis [17], [18], [19], [20]. This evidence concerns the gene IL10 and neoplasm.