Although an overproduction of the endolymph has been proposed, it seems more probable that a defect in the absorptive activity of the endolymphatic duct and sac is present.[16] Many studies indicate a possible role of antidiuretic hormone (ADH) in the pathogenesis of Meniere’s disease, and especially in the mechanism of induction of the endolymphatic hydrops. The gene discussed is AVP; the disease is Meniere disease.