In patients with ARDS, high-dose corticosteroids have been shown to reduce the levels of the cytokines TNF-α, interleukin (IL)-1β, IL-6, and IL-8.[55] However, Medin et al.[54] demonstrated that no reduction was seen in IL-8 after treatment with dexamethasone in patients with dengue. This evidence concerns the gene CXCL8 and acute respiratory distress syndrome.