Theshuttle/transport protein lipocalin 2 (LCN2) is also of particular interest:lipocalin 2 was identified as one half of a complex with matrix metalloproteinaseMMP-9 that is elevated in the urine of cancer patients (notably breast, bladder,pancreas and prostate) [46], [47], and it also forms part of a common gene signature forhormone independence in breast and prostate cancer [29]. Here, LCN2 is linked to Familial prostate cancer.