AR and neoplasm: A global screening approach may be required to determine if it ispossible for DU145 or PC-3 cells to trans-differentiate towards a luminal phenotypethat is dependent upon AR function but this may not be possible for the former asloss of AR expression is associated with promoter methylation (Sasaki et al, 1992).However, this approach may be viable for PC-3 cells as well as those hormonerefractory tumours where loss of (or reduced) AR expression is not associated withpromoter methylation [68], [69].