HH/GLI signalling regulates normal and cancer stem cell populations and recentstudies have described how EMT is an inherent trait of such cells [15], [16], [33].Interestingly, despite their cobblestone-like morphology, the results of themicroarray revealed that eGLI1 induces EMT in LNCaP cells (Figure S3).Indeed, decreased E-Cadherin and increased vimentin expression was confirmed byWestern blotting, although this was not dependent upon EGFR or MEK-ERKsignalling [34](Fig. 4A). The gene discussed is VIM; the disease is cancer.