We found significantly lower plasma levels of leptin in AD patients compared withhealthy controls (Fig. 1A), whereas plasma levels ofadiponectin did not show any significant differences (AD vs. control(mean±SD): leptin: 8.9±5.6 ng/mL vs. 16.3±15.5 ng/mL;P = 0.038; adiponectin: 18.5±18.1 μg/mL vs.16.7±8.9 μg/mL; P = 0.641) (Fig.1B). Here, LEP is linked to Alzheimer disease.