Up-regulated expression of MICA/B on the tumor cell surface has been considered a "danger signal" in order to activate NKG2D-expressing cells and promote anti-tumor immunity [4,13,42] However, numerous studies have demonstrated tumor evasion through metalloprotease-induced proteolytic release of MICA and MICB from the cell surface, which provokes down-regulation of NKG2D in NK and T cells [44-47]. The gene discussed is MICB; the disease is neoplasm.