Therefore, an issue of vital importance will be to address if both soluble MICA and MICB share the same biological function in patients with HPV-associated tumors and to determine whether MICB, which was found in a higher concentration than MICA in the supernatants of cervical cancer cell lines, could promote NKG2D downmodulation in NK cells of cervical cancer patients. Here, MICA is linked to cervical carcinoma.