Therefore, an issue of vital importance will be to address if both soluble MICA and MICB share the same biological function in patients with HPV-associated tumors and to determine whether MICB, which was found in a higher concentration than MICA in the supernatants of cervical cancer cell lines, could promote NKG2D downmodulation in NK cells of cervical cancer patients. This evidence concerns the gene KLRK1 and cervical cancer.