Tight glycemic control has been established as the cornerstone of effective diabetes management in European and US studies,7–11 as well as in studies of Asian patients.12 Based on such data, the International Diabetes Federation (IDF) Western Pacific Region has proposed a preferred target of A1c ≤ 6.5% for Asian patients with T2DM.13,14 The American Diabetes Association (ADA)/European Assocaiton for the Study of Diabetes (EASD) consensus statement15 suggests an A1c target of <7% and recommends early initiation of insulin in patients not meeting A1c targets. Here, INS is linked to diabetes mellitus.