POLE2 and neoplasm: In a re-analysis of those data, one prominentgene-expression feature (Fig.1A) included genes regulating the cell-cycle (e.g. CCNE1,CDK1, CDC25A), and involved in DNA replication(e.g. POLE2, MCM4, TK1) andchromosome dynamics (e.g. SMC4, CENPE), ostensiblyreflecting tumor cell proliferation levels.