The B8-TrCP TFB fusion protein or ALcB8 alone were expressed within BoNT/A intoxicated neuroblastoma Neuro 2A (N2A) cells together with the ALc substrate, SNAP25, expressed as an indicator protein flanked by yellow fluorescent protein (YFP) and cyan fluorescent protein (CFP) [26]. The gene discussed is CFP; the disease is neuroblastoma.