A further schizophrenia animal model is represented by the Df1/+ mouse because it carries a hemizygous deletion from Es2 to Ufd1l (referred to as Df1 [99]), a region syntenic with a human 22q11 deletion causing DiGeorge syndrome; 35% of the DiGeorge syndrome patients develop schizophrenia [100]. Here, ESS2 is linked to 22q11.2 deletion syndrome.