In contrast, the expression of the miR-16 family has been shown to be suppressed >1.5-fold by c-Myc and lin28B in B-cell lymphomas (Chang et al, 2008, 2009), which mirrors the preliminary HBx-c-Myc-miR-15a/16 pathway found in our study. This evidence concerns the gene LIN28B and B-cell non-Hodgkin lymphoma.