Additionally, HER2 Delta 16 suppresses miR-15a/16 and deregulates BCL-2 to promote endocrine resistance in breast tumours (Cittelly et al, 2010), whereas PKC alpha downregulates miR-15a in head and neck squamous cell carcinoma (Cohen et al, 2009). This evidence concerns the gene BCL2 and head and neck squamous cell carcinoma.