CD8A and hepatocellular carcinoma: Han et al (2008) found an independent positive effect of either CD3+ or CD8+ compared with no CD3+ or CD8+ in ovarian cancer. In gastric cancer, Lee et al (2008) observed that high numbers of both CD3+ and CD8+ are favorable compared with low numbers of both cell types. Finally, Kobayashi et al (2007) found that high numbers of CD8+ compared with CD3+ was not a prognostic factor in hepatocellular cancer.