Both the US Food and Drug Administration (FDA) and the European Agency for the Evaluation of Medical Products (EMEA) have approved GH for the treatment of short stature in children born SGA and Silver-Russell syndrome, provided that other causes of short stature are excluded, such as growth-inhibiting medication, chronic diseases, endocrine disorders, emotional deprivation, or syndromes associated with short stature. This evidence concerns the gene GH1 and endocrine system disorder.