However, given the importance of the LINC complex for nervous system development [23], it is conceivable that torA-ΔE driven abnormalities in LINC complex mediated events impact neuronal development to generate the circuit abnormalities that are thought to underlie the debilitating twisting movements of DYT1 dystonia [42]. Here, TOR1A is linked to early-onset generalized limb-onset dystonia.