PTGS2 and Venous thrombosis: As regards the main concerns recently emerged about the possible, dose-related, cardiovascular toxicity associated with chronic exposure to COX-2 inhibitors [23], notwithstanding enrolled patients were submitted to a median of 3 months of celecoxib-carboplatin, no serious cardiovascular events was reported in our study population: only one patients experienced a grade 1 venous thrombosis, recovering after two weeks of therapy.