siRNA-mediated knockdown of S100A8/A9 expression significantly reduced H-Ras-induced invasion/migration; Induction confers the invasive/migratory phenotype [52]; Immunopositivity correlates with mitotic activity, MIB-1 index, HER2 overexpression, node metastasis, and poor prognosis [65]; Associated with transformation and progression of breast cancer cells which is reversed by treatment with silencing inhibitors [53]; Down-regulated in invasive tumors [66]. The gene discussed is IGKV1D-22; the disease is breast cancer.