However, recent advances in genome wide association study (GWAS) techniques have permitted the isolation of four uncontroversial meta-GWAS-significant (P < 5 × E-8) genetic markers associated with AD, which are located near the CLU (clusterin), PICALM (phosphatidylinositol binding clathrin assembly protein), CR1 (complement component (3b/4b) receptor 1) and BIN1 (bridging integrator 1) genes [6-8]. This evidence concerns the gene PICALM and Alzheimer disease.