In addition to an impaired migratory potential, a weaker induction of local MCP-1 production was observed in CD38−/− than in wildtype mice after stroke, despite a similar initial ischemic brain damage indicated by comparable neurological impairment and similar elevations of MCP-1 levels in peripheral blood 6 h after tMCAO illustrating adequate systemic immune responses. The gene discussed is CD38; the disease is stroke disorder.