CD8A and infection: Based on all these results, we hypothesized that after MVA-B infection at an optimal dose of 0.3 PFU/MDDC, approximately one third of the MDDC culture is infected, resulting in their apoptosis and converted into apoptotic bodies, while approximately the other two thirds of the initial mature MDDC would remain uninfected, being able to engulf the cell debris containing MVA-B-mediated HIV-1 expressed antigens and to maturate properly and, thus, cross-present the HIV antigens to CD8+ T lymphocytes.