In fact, pharmacological IKKβ-inhibition was reported to induce beneficial effects in various animal models of inflammatory diseases like collagen-induced arthritis [81] and MOG33–55-induced experimental autoimmune encephalomyelitis (EAE) [82], although the impact on the generation of Th17 cells was not investigated in those studies. Here, IKBKB is linked to experimental autoimmune encephalomyelitis.