No correlations of2B4 expression frequency on total CD8+ T cells with viral load, AST or ALTlevels or other clinical marker of liver disease could be seen (data not shown).In addition, 2B4 expression was studied on liver-infiltrating CD8+ T cellsfrom healthy liver tissues which stained highly 2B4-positive in 85% to98% of cases (mean 79% ±17.5%, see Figure 1c) with higherrelative levels of 2B4 expression (average MFI 214±66.7, data not shown)as compared to peripheral lymphocytes (Figure 1c). This evidence concerns the gene CD8A and liver disorder.