CD8A and hepatitis B virus infection: We therefore used PBMCsobtained from patients with chronic hepatitis C infection, patients with acutesymptomatic hepatitis C and hepatitis B virus infection and analyzed 2B4expression by flow cytometry in comparison to samples from healthy individuals.Generally, the frequency of 2B4 expression on bulk CD8+ T cells showed alarge inter-individual variability in all cohorts analyzed (Figure 1c).