We next investigated 2B4 expression on CMV-, EBV- and Flu-specific CD8+ Tcells in patients with chronic hepatitis C. A higher frequency of 2B4 expressionon Flu-specific cells was detected as compared to healthy individuals (Figure 1e, left panel) whileno difference was seen for CMV- or EBV-specific CD8+ T cells. The gene discussed is CD8A; the disease is chronic hepatitis C virus infection.