Moreover and importantly, SAPexpression differed between 2B4hi and 2B4lo CD8+ Tcells as SAP levels were significantly lower in 2B4hi cells in bothhealthy individuals (MFI 1361±821 vs. 1566±994;p = 0.02), chronic hepatitis C patients (MFI1023±734 vs. 1170±698; p = 0.005) andintrahepatic T cells (MFI 807±255 vs. 1045±222;p = 0.03; see Figure 5b and 5c). The gene discussed is CD8A; the disease is chronic hepatitis C virus infection.