The level of 2B4 expression onHCV-specific CD8+ T cells in patients with chronic hepatitis C seemed to belower in subjects showing viral sequence variants in the respective epitopes.However, in those individuals where the viral sequence was matching to thepeptide sequences used not only high 2B4 MFIs could be observed onvirus-specific CD8+ T cells, but also low expression levels of 2B4 could befound (see online Supplementary Table S1). This evidence concerns the gene CD244 and chronic hepatitis C virus infection.