[8] HF also induces remodeling of IKr, but there is no widespread consensus on suppression or enhancement of IKr in previous studies.[9], [10] Furthermore, despite the incremental progress in understanding intrinsic IKr modulators, to our knowledge, there has been no report of naturally occurring substances with a KCNH2 current-activating effect in patients with HF. This evidence concerns the gene KCNH2 and hydrops fetalis.