It will be of great interest to uncover if exploitation of subcellular stress by pathogens is a generalized phenomenon that occurs in prion diseases, Parkinson's disease (α-synuclein), amyotrophic lateral sclerosis (superoxide dismutase-1), hereditary emphysema (α-1-antitrypsin), familial neurohypophyseal diabetes insipidus (arginine vasopressin), or many other disorders that stem from misfolded or unfolded proteins [73]. The gene discussed is SOD1; the disease is prion disease.