PKD2L1 and polycystic kidney disease: Though many candidate sourtaste receptors have been implicated in detection, such as acid sensing ion channels(ASICs; [2]),hyperpolarization activated cyclic nucleotide gated potassium channels (HCNs; [3]), potassiumchannels [4], [5], NPPB sensitiveCl− channels [6], and polycystic kidney disease 1L3 and 2L1 heteromers(PKD1L3+PKD2L1, [7], [8]), none of them has a demonstrated role in sour tastesensation in loss of function animals.