FGF2 and small cell lung carcinoma: As observed for SCLC cells [8], the reduction of cell death by FGF-2 could be prevented by inhibition of mitogen-activated protein kinase kinase (MEK)/ERK activity with a selective inhibitor (Fig. S2), whilst inhibition of phosphatidylinositol 3-kinase (PI3K) and target of rapamycin complex (TORC) 1 signaling had no impact (data not shown).