Calcium signaling represents a general mechanism of intercellular signaling via the gap junction-mediated diffusion of Ca2+/inositol 1,4,5-triphosphate [37]; cancer cell transformation, cell proliferation and cell death are associated with a major rearrangement of Ca2+ pumps, Na/Ca exchangers and Ca2+ channels, which leads to enhanced proliferation and an impaired ability to die that ultimately determines cell fate [38]. Here, SLC8A1 is linked to cancer.