These HCC-associated genes include AFP, β-catenin, cyclin B1, c-myc, FOXO1A, IFNAR1, SOCS2, EGF, E-cadherin, CDKN2A, and IGFBP3 etc. Interestingly, more than half of the selected genes showed alterations in their expression. This evidence concerns the gene SOCS2 and hepatocellular carcinoma.