For example, IL-22 was highly expressed in non-small cell lung carcinoma, and the overexpression of IL-22 protected lung cancer cell lines from serum starvation-induced and chemotherapeutic drug-induced apoptosis; furthermore, administration of IL-22-RNAi significantly inhibited human lung tumor cell growth in BALB/c nude mice [28]. This evidence concerns the gene IL22 and non-small cell lung carcinoma.