When assayed on the human glioblastoma cell line U87 MG described previously as expressing a low level of RPTPβ/ζ [44], P111-136 inhibited the colony formation in a lesser extent (data not shown) supposing that an optimal expression of both ALK and RPTPβ/ζ receptors could be important for a strong effect of P111-136. The gene discussed is ALK; the disease is glioblastoma.