TP53 and Li-Fraumeni syndrome: We also investigated many of the genes with germline mutations in cancer predisposition syndromes associated with an increased frequency of OS [15], including the DNA repair genes TP53 (mutated in Li-Fraumeni Syndrome), WRN (mutated in Werner syndrome), BLM (mutated in Bloom syndrome), RECQL4 (mutated in Rothmund-Thomson Syndrome), and the ribosomal genes RPS19 and RPS24 (mutated in Diamond-Blackfan anemia) [28,47,48].