TF and neoplasm: After binding of FVIIa, the TF forms a high affinity complex with FVIIa or FVIIa-FXa, and other than initiating the coagulation cascade, the complex induce signal transduction by binding to a family of transmembrane domain G protein-coupled cell surface receptors called protease-activated receptors (PARs), specially, PAR-1/-2 [32], which are expressed by numerous tumor cells and tissues [33,34].