Despite reduced f-TFPI and increased vWF and PAI-1 levels - all apparent procoagulant factors and markers of endothelial dysfunction - myocardial infarction did not occur in our series and has not been a frequent finding in the follow-up of larger series of patients with VA without significant stenosis [18,19] or patients with NVA [20-22]. This evidence concerns the gene SERPINE1 and endothelial dysfunction.