Thus, while Soejima [10] reported that increased levels of f-TFPI in patients with unstable angina were associated with increased risk of unfavorable outcomes, Morange demonstrated that reduced rather than increased f-TFPI plasma level was an independent risk factor for myocardial infarction in 10.000 healthy men being an even better predictor when associated with increased levels of vWF [32]. This evidence concerns the gene TFPI and angina unstable.