ADRB3 and obesity due to melanocortin 4 receptor deficiency: In this pilot study, we looked for the association of the Arg64 minor allele of the ADRB3 Trp64Arg gene polymorphism with obesity, defined by high BMI (> 25 kg/m2) and WC (≥ 80 cm for female and ≥ 90 cm for male, respectively) [17].