Small sample size and low minor allele frequency would reduced the statistical power, however, we have carefully analyze the statistics, thus the results obtained would have reliable statistical power, and still noteworthy, as they provide preliminary valuable information on the association of ADRB3 Trp64Arg gene polymorphism with obesity and MetS, specifically the different genetic effect in urban and rural Balinese. This evidence concerns the gene ADRB3 and Obesity.