AKT1 and Insulin resistance: On the other hand, Akt is also involved in insulin desensitization (Pirola et al., 2003; Tajmir et al., 2003; Bertacca et al., 2005), and increased Akt has been detected in several models of insulin resistance (Pirola et al., 2003; Tajmir et al., 2003; Bertacca et al., 2005; Chakraborty, 2006).