Next, we addressed whether clozapine may affect the cellular content of Ped/Pea-15, an Akt substrate (Trencia et al., 2003), whose overexpression causes insulin resistance in cellular and animal models (Condorelli et al., 1998; Vigliotta et al., 2004) and associates to insulin resistance in humans (Valentino et al., 2006). Here, AKT1 is linked to Insulin resistance.