APOH and autoimmune disease: As shown in Figure 2A, the concentration of total β2GPI was significantly higher in the APS group (median 216.2 μg/ml [IQR 173.3–263.8]) (n = 139) as compared to the healthy control group (P < 0.0002), the autoimmune disease control group (P < 0.0001), and the clinical event control group (P < 0.0001).