The activated membrane ER induces the discretion of the G-protein α subunit to trigger the activation of Src kinases and PI3 kinase (PI3-K), respectively followed by downstream protein kinase C (PKC) and kinase cascade to extra-cellular regulated protein kinase (Erk), which are involved in proliferation and survival of breast cancer cells [47]. This evidence concerns the gene PRRT2 and breast carcinoma.