IL6 and ovarian carcinoma: With regard to phytoestrogenic functions on modulating intracellular signals to affect the ovarian cancer growth [red hammers and blue arrows in Fig. 3], the previous research on the isoflavones showed that genistein and daidzein were capable of altering cytokine (interleukin-6) synthesis and attenuating ovarian cancer cell proliferation through activating the nuclear ER-dependent pathway [69, Fig. 3-(1)].