IGHE and chronic rhinosinusitis: Until now, evidence for SAE involvement in the pathogenesis of upper airway disease like chronic rhinosinusitis with nasal polyposis (CRSwNP), arises from the finding that IgE against SEA and SEB has been demonstrated in nasal polyps [12] and levels of SAE-specific IgE in nasal polyposis correlated with markers of eosinophil activation and recruitment [13].